Antimicrobial resistance (AMR) poses an increasing threat to patient care and population health and there is a growing need for novel therapies to tackle AMR. Bacteriophage (phage) therapy is a re-emerging antimicrobial strategy with the potential to transform how bacterial infections are treated in patients and populations. Currently, in the UK, phages can be used as unlicensed medicinal products on a ‘named-patient’ basis. We make an ethical case for why it is crucially important for the UK to invest in Good (...) Manufacturing Practice (GMP) for both ongoing unlicensed and future licensed phage therapy. Access to phages produced to GMP (GMP phages) will ensure effective patient care and better outcomes as well as health systems benefits. The UK also has the potential to become a global leader in the timely and cost-efficient manufacturing and supply of a therapy that meets internationally recognised standards. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Stephen R. L. Clark has authored twelve books covering three philosophical themes: religion, duties toward animals, and politics—“Unfortunately, however, those familiar with one realm of his work, tend not to be familiar with what he has done in other areas”. Even those who may be familiar with the whole of Clark’s corpus may find it difficult to discern a coherent philosophical message among these disparate themes. Dombrowski seeks to present a comprehensive overview of Clark’s thought, and to (...) elucidate Clark’s primary philosophical concerns and prejudices, which run through all his works. However, Dombrowski’s admiration for Clark’s philosophy does not preclude him from offering his own unique analysis and critique. (shrink)

This paper attempts to explain the conceptual connections between happiness and well-being. It first distinguishes episodic happiness from happiness in the personal attribute sense. It then evaluates two recent proposals about the connection between happiness and well-being: (1) the idea that episodic happiness and well-being both have the same fundamental determinants, so that a person is well-off to a particular degree in virtue of the fact that they are happy to that degree, and (2) the idea that happiness in the (...) personal attribute sense can serve as a ‘‘proxy’’ for well-being, i.e., that a person’s degree of deep or robust happiness approximates their degree of well-being. It is argued that happiness in both these senses is conceptually, metaphysically, and empirically distinct from well- being. A new analysis of welfare, well-being as agential flourishing, can explain welfare’s real connection to happiness in both the episodic and personal attribute senses. It predicts that such happiness is only directly beneficial when it is valued, when it is a form of valuing, or when it underwrites (i.e., serves as the causal basis for) the disposition to realize one’s values. It is therefore a necessary—but not sufficient—condition for especially high levels of well-being. This analysis of welfare integrates many insights from the eudaimonic tradition of welfare and happiness research in psychology, and also addresses common criticisms of these eudaimonic models. (shrink)

The values-based approach to welfare holds that it is good for one to realize goals, activities, and relationships with which one strongly (and stably) identifies. This approach preserves the subjectivity of welfare while affirming that a life well lived must be active, engaged, and subjectively meaningful. As opposed to more objective theories, it is unified, naturalistic, and ontologically parsimonious. However, it faces objections concerning the possibility of self-sacrifice, disinterested and paradoxical values, and values that are out of sync with physical (...) and emotional needs. This paper revises the values-based approach, emphasizing the important—but limited—role consciously held values play in human agency. The additional components of human agency in turn explain why it is important for one’s values to cohere with one’s fixed drives, hard-wired emotional responses, and nonvolitionally guided cognitive pro- cesses. This affords promising responses to the objections above. (shrink)

Abstract Theories of personal well-being are typically developed so that they render verdicts on (a) how well-off a person is at a moment, (b) how well-off a person is over an interval of time, and (c) how good a whole life is for the person who lives it. Conative theories of welfare posit welfare-atoms that consist, e.g., in episodes of desire-satisfaction, aim-achievement, or values-realisation. Most extant conative theories are additive: they compute well-being over time - up to and including the (...) value of a whole life - by adding up the values of these welfare atoms. Here, it is shown that such atomistic, additive conative theories do not always generate plausible verdicts on (b) and (c) above. They imply that lives featuring incoherent plans and rapidly changing projects go surprisingly well for those who lived them. Holistic theories of well-being are often thought to provide a solution to problems like these. However, one of the best-known versions of welfare holism within the conative family, Rawls? rational life-preferentism, is based on the problematic assumption that there is one ideal life plan for each person. This paper presents a new form of paradigm-resemblance based conative holism that does not make this assumption and that explains the limits of additivity. (shrink)

How is technology changing the way people remember? This book explores the interplay of memory stored in the brain and outside of the brain, providing a thorough interdisciplinary review of the current literature, including relevant theoretical frameworks from across a variety of disciplines in the sciences, arts, and humanities. It also presents the findings of a rich and novel empirical data set, based on a comprehensive survey on the shifting interplay of internal and external memory in the 21st century. Results (...) reveal a growing symbiosis between the two forms of memory in our everyday lives. The book presents a new theoretical framework for understanding the interplay of internal and external memory, and their complementary strengths. It concludes with a guide to important dimensions, questions, and methods for future research. Memory and Technology will be of interest to researchers, professors, and students across the disciplines of psychology, philosophy, library and information science, human factors, media and cultural studies, anthropology and archaeology, photography, and cognitive rehabilitation, as well as anyone interested in how technology is affecting human memory. _____ "This is a novel book, with interesting and valuable data on an important, meaningful topic, as well as a gathering of multidisciplinary and interdisciplinary ideas...The research is accurately represented and inclusive. As a teaching tool, I can envision graduate seminars in different disciplines drawing on the material as the basis for teaching and discussions." Dr. Linda A. Henkel, Fairfield University "This book documents the achievements of a vibrant scientific project – you feel the enthusiasm of the authors for their research. The organization of the manuscript introduces the reader into a comparatively new field the same way as pioneering authors have approached it." Prof. Dr. Wolfgang Schönpflug, Freie Universität Berlin. (shrink)

Arguments for slavery reparations have fallen out of favor even as reparations for other forms of racial injustice are taken more seriously. This retreat is unsurprising, as arguments for slavery reparations often rely on two normatively irregular claims: that reparations are owed to the dead (as opposed to, say, their living heirs), and that the present generation inherits an as yet unrequited guilt from past generations. Outside of some strands of Black thought and activism on slavery reparations, these claims are (...) widely rejected. I develop an argument for slavery reparations around those foundational claims by adopting the normative framework of Immanuel Kant. On what I call the Basic Argument for slavery reparations, the application of Kant’s retributivist theory of punishment to slavery justifies reparations as a kind of proportional punishment for slavery. I also show that Kant’s philosophy offers reparations theorists resources to overcome several contemporary objections to slavery reparations. (shrink)

Black Knowledges/Black Struggles: Essays in Critical Epistemology explores the central, but often critically neglected role of knowledge and epistemic formations within social movements for human emancipation. This collection examines the systemic connection that exists between the empirical subordination of "Black" peoples globally and the conceptual negation that subordinates or renders this population invisible within the epistemes of the West. The collection recognizes that as peoples of "Black" African and Afro-mixed descent mobilize against their dehumanized status within Western modernity, they are (...) involved in a struggle that is both contemporary and of long standing, one where local and national battles have a global dimension. The essays in this collection foreground the extent to which liberation from imposed subordination necessarily entails critiques of, challenges to, and counter-formulations against the epistemic formations that work to "naturalize" subordination. The essays in the collection engage primarily with knowledge formations and empirical practices generated from within the discourse of "race," but also in its relation to other socio-human discourses of Western modernity. These essays also analyze the critiques, challenges, and counter-knowledge/epistemic formulations put forth by specific individuals, schools, movements, and/or institutions of the "Black" world. Through these examinations, the collection's authors implicitly point towards, and sometimes explicitly take part in, the formulation of a new kind of critical - but also emancipatory - epistemology. What emerges is a more comprehensive view of what it means to be human, an epistemic construction that can serve as an instrument of liberation rather than subordination. (shrink)

This dissertation develops a theory of personal well-being---i.e., a theory of what is it for a person's life to go well for them. The proposed theory is called "the successful activity view of well-being." It is an end-neutral account of individual welfare that primarily values the pursuit, achievement, and enjoyment of ends that are important to a person. The parts of this process---e.g., the pursuit of ends, the achievement of ends, the enjoyment of activities and situations, and even the satisfaction (...) of desires for situations---are also of some significance for a person's level of well-being when actualized separately. I argue that previous end-neutral accounts of well-being, such as hedonism and desire-satisfactionism, are open to damaging objections because pleasures and desires can fail to coincide with a person's values. I also argue that the successful activity view has greater unity, explanatory power, and ontological economy than any form of perfectionism or any hybridized theory of wellbeing currently on offer.^. (shrink)

I argue that Hume’s characterization of the passions as “original existences” is shaped by his preoccupation with Stoicism, and is not (as most commentators suppose) a ridiculous or trifling remark. My argument has three parts. First, I show that Hume’s description of the passions as “original existences” is properly understood as part of his argument against the possibility of passions caused by reason alone (rational passions). Second, I establish that Hume was responding to the Stoics, who claimed that a rational (...) passion is caused by a special type of impression that accurately represents its cause—the divine reason administrating the cosmos—in virtue of resembling it. Third, I argue that Hume rejects the Stoics’ claim by appeal to the following feature of his general account of impressions and ideas: for Hume, ideas are exact “copies” or representations of the impressions that caused them, but simple impressions are “originals” that do not represent in virtue of resembling their external or physiological causes. On my reading of Hume, the ‘original existence’ passage therefore signals his rebuke of a key claim in the Stoics’ theory of rational passions. (shrink)

Socioeconomic inequality is perpetuated and exacerbated by an overlooked yet serious epidemic of time theft: the act of causing others to lose their time without adequate cause, compensation, or consent. We explain why time theft goes unnoticed, how it drives socioeconomic inequality, and what businesses and policymakers can do to address it.

Hume is widely read as committed to a kind of anti-realism about secondary qualities, on which secondary qualities are less real than primary qualities. I argue that Hume is not an anti-realist about secondary qualities as such, and I explain why Hume’s remarks on the primary-secondary distinction are better read as abstaining from the realist/anti-realist debate as it was understood by modern philosophers such as Locke. By contextualizing Hume’s discussion of the primary-secondary distinction in Treatise 1.4.4 as a response to (...) a broadly Lockean understanding of the distinction, my analysis retrieves Hume’s critique of the resemblance and inseparability theses that structure Locke’s version of the distinction and establishes that Hume has epistemic reasons to reject Locke’s metaphysical conclusions about the distinction. (shrink)

Men typically express more willingness than women to perpetrate fraudulent acts like lying in negotiations. However, women express just as much willingness in some cases. We develop and test a theory to explain these mixed findings. Specifically, we hypothesize that situational cues that bring about competitive or empathic feelings mitigate sex differences in lying to negotiation counterparts. Results from four experiments confirm our hypotheses. Experiment 1 showed that men and women express equal willingness to lie when negotiating with counterparts toward (...) whom they felt either great competitiveness or empathy. Experiment 2 extended these results by confirming that men only express more willingness to lie absent competitive or empathic feelings towards a counterpart. Experiments 3 and 4 demonstrated that inducing competitive or empathic feelings toward a counterpart eliminated sex differences in lying by leading women to lie more and men to lie less, respectively. Overall, our results suggest that the extent to which negotiators experience competitive or empathic feelings play important roles in whether sex differences in lying in negotiations emerge. (shrink)

In God's World and the Great Awakening, Professor Clark's main concern is with the way we can `turn aside' to the Truth from the normal delusions of self-concern. He restates a traditional, Neoplatonic metaphysics as the proper context for scientific and religious practice, and defends a serious Platonic realism against both scientism and anti-realism. Neither scientism, which identifies Truth with what can be revealed to the objectifying gaze, nor fashionable anti-realism, which equates Truth simply with what `we' choose to (...) take seriously, offer an adequate ground for our scientific or religious faith. The primary faith of humankind is that there is a real world which is more than an obsequious shadow of our desires and fancies, and this real world can be discovered through right reason. The defence of this faith requires a properly worked, Platonic metaphysic of just the kind discernible in Christian orthodoxy.The other two volumes are: Civil Peace and Sacred Order and A Parliament of Souls. (shrink)

The current revolution in biological microscopy stems from the realisation that advances in optics and computational tools and automation make the modern microscope an instrument that can access all scales relevant to modern biology – from individual molecules all the way to whole tissues and organisms and from single snapshots to time‐lapse recordings sampling from milliseconds to days. As these and more new technologies appear, the challenges of delivering them to the community grows as well. I discuss some of these (...) challenges, and the examples where openly shared technology have made an impact on the field. (shrink)

In response to Mandler , I argue in this comment that a more unified psychology generally, and a more unified experimental, scientific psychology specifically, are more difficult to obtain than he suggests. Furthermore, I contend that Mandler does not sufficiently maintain a clear distinction between disciplinary psychology generally, and experimental, scientific psychology, specifically in his discussions of broaching greater unity. This distinction is particularly important, as how it is treated has serious implications for the many specializations and schools of thought (...) within disciplinary psychology that do not fall under the umbrella of experimental, scientific psychology—and, at minimum, these other areas of psychology constitute a large minority of disciplinary psychology. As a specific example, I argue that Mandler's treatment of psychodynamic/psychoanalytic perspectives belies an experimental, scientific psychology bias, which does not do justice to these important perspectives on their own terms. I also highlight some important theoretical divisions that Mandler overlooks. 2012 APA, all rights reserved). (shrink)

ABSTRACTClose relationship partners often respond to happiness expressed through smiles with capitalization, i.e. they join in attempting to up-regulate and prolong the individual’s positive emotion, and they often respond to crying with interpersonal down-regulation of negative emotions, attempting to dampen the negative emotions. We investigated how people responded when happiness was expressed through tears, an expression termed dimorphous. We hypothesised that the physical expression of crying would prompt interpersonal down-regulation of emotion when the onlooker perceived that the expresser was experiencing (...) negative or positive emotions. When participants were asked how they would behave when faced with smiles of joy, we expected capitalization responses, and when faced with tears of joy, we expected down-regulation responses. In six experimental studies using video and photographic stimuli, we found support for our hypotheses. Throughout our investigations we test and discuss boundaries of and poss... (shrink)

This study examined the efficacy of corrected feedback for improving consent recall throughout the course of an ongoing longitudinal study. Participants were randomly assigned to either a corrected feedback or a no-feedback control condition. Participants completed a consent quiz 2 weeks after consenting to the host study and at months 1, 2, and 3. The corrected feedback group received corrections to erroneous responses and the no-feedback control group did not. The feedback group displayed significantly greater recall overall and in specific (...) content areas. Results support the use of corrected feedback for improving consent recall. (shrink)

The effectiveness of information retrieval technology in electronic discovery (E-discovery) has become the subject of judicial rulings and practitioner controversy. The scale and nature of E-discovery tasks, however, has pushed traditional information retrieval evaluation approaches to their limits. This paper reviews the legal and operational context of E-discovery and the approaches to evaluating search technology that have evolved in the research community. It then describes a multi-year effort carried out as part of the Text Retrieval Conference to develop evaluation methods (...) for responsive review tasks in E-discovery. This work has led to new approaches to measuring effectiveness in both batch and interactive frameworks, large data sets, and some surprising results for the recall and precision of Boolean and statistical information retrieval methods. The paper concludes by offering some thoughts about future research in both the legal and technical communities toward the goal of reliable, effective use of information retrieval in E-discovery. (shrink)

This is an edited collection containing papers on intrinsic value, consequentialism, the evil of death, among others.

This is the first of two volumes of essays in commemoration of Alan Turing, whose pioneering work in the theory of artificial intelligence and computer science continues to be widely discussed today. A group of prominent academics from a wide range of disciplines focus on three questions famously raised by Turing: What, if any, are the limits on machine `thinking'? Could a machine be genuinely intelligent? Might we ourselves be biological machines, whose thought consists essentially in nothing more than the (...) interaction of neurons according to strictly determined rules? The discussion of these fascinating issues is accessible to non-specialists and stimulating for all readers. (shrink)

The author narrates briefly the friendship that developed from his instruction of James Dean in the art of photography and documents the Dean personality with exclusive portraits.

An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of human in vitro model systems, such as human pluripotent stem cell‐derived tissue, have led to a growing understanding of the mechanisms governing human lung development. They have illuminated key differences between animal models and humans, underscoring the need for continued advancements in modeling human lung development and utilizing (...) human tissue. This review discusses the use of human tissue and the use of human in vitro model systems that have been leveraged to better understand key regulators of human lung development and that have identified uniquely human features of development. This review also examines the implementation and challenges of human model systems and discusses how they can be applied to address knowledge gaps. (shrink)

Freedom of information laws promote transparency by permitting individuals and organizations to obtain government documents. However, exemptions from disclosure are necessary to protect privacy and to permit government officials to deliberate freely. Deliberative language is often the most challenging and burdensome exemption to detect, leading to high processing costs and delays in responding to open-records requests. This paper describes a novel deliberative-language detection model trained on a new annotated training set. The deliberative-language detection model is a component of a decision-support (...) system for open-records requests under the US Freedom of Information Act, the FOIA Assistant, that ingests documents responsive to an open-records requests, suggests passages likely to be subject to deliberative language, privacy, or other exemptions, and assists analysts in rapidly redacting suggested passages. The tool’s interface is based on extensive human-factors and usability studies with analysts and is currently in operational testing by multiple US federal agencies. (shrink)

Recently, many critics have argued that disgust is a morally harmful emotion, and that it should play no role in our moral and legal reasoning. Here we defend disgust as a morally beneficial moral capacity. We believe that a variety of liberal norms have been inappropriately imported into both moral psychology and ethical studies of disgust: disgust has been associated with conservative authors, values, value systems, and modes of moral reasoning that are seen as inferior to the values and moral (...) emotions that are endorsed by liberal critics. Here we argue that the meta-ethical assumptions employed by the critics of disgust are highly contentious and in some cases culture bound. Given this, we should avoid adopting simplified meta-ethical positions in experimental moral psychology, as these can skew the design and interpretation of experiments, and blind us to the potential value of moral disgust harnessed in the service of liberal ends. (shrink)

We examined the efficacy of including a research intermediary (RI) during the consent process in reducing participants' perceptions of coercion to enroll in a research study. Eighty-four drug court clients being recruited into an ongoing study were randomized to receive a standard informed consent process alone (standard condition) or with an RI (intermediary condition). Before obtaining consent, RIs met with clients individually to discuss remaining concerns. Findings provided preliminary evidence that RIs reduced client perceptions that their participation might influence how (...) clinical and judicial staff view them. This suggests that using RIs may improve participant autonomy in clinical studies. (shrink)

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic and dizygotic twins, and the shared/unique contribution of genetic and environmental variance. Using linear mixed models, mental well-being was positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory, whereas depression and anxiety symptoms were (...) associated with poorer sustained attention, inhibition, cognitive flexibility and executive function. Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables. (shrink)

The notion that metaphorical statements are strictly false suggests that all statements, even those that seemed ‘literal’, are false, as none can ‘literally’ reflect reality. Statements about what we perceive or could perceive rely on evoking sensory images of such ‘visibles’, even though we have no direct access to what others, may perceive. In addition to what is visible, we must also deal with ‘invisibilia’ (both the fantasms that respectable moderns now reject and the realities that lie beyond or before (...) all sentient experience). Talking about such distant or long-ago realities must always be ‘metaphorical’, as they cannot have any of the merely ‘subjective’ properties of experience, nor do they explain those latter properties. Is there some way of confirming the brute conviction that there is a ‘real and intelligible world’, and that we can find it out or describe it ‘literally’? May ‘Reason’ be a route to understanding? But this too is an illusion: we seem never in practice to escape contradictions and had perhaps better turn again to consider the worlds of experience to which we are confined. What we experience is conditioned by our imagination: whether that metaphorical imagination points beyond experience remains uncertain. (shrink)

Many religious people are alarmed about features of the current age - violence in the media, a pervasive hedonism, a marginalization of religion, and widespread abortion. These concerns influence politics, but just as there should be a separation between church and state, so should there be a balance between religious commitments and secular arguments calling for social reforms. Robert Audi offers a principle of secular rationale, which does not exclude religious grounds for action but which rules out restricting freedom except (...) on grounds that any rational citizen would accept. The book describes the essential commitments of free democracy, explains how religious and secular moral considerations can be integrated to facilitate co-operation in a world of religious pluralism, and proposes ideals of civic virtue that express the mutual respect on which democracy depends. Audi offers a balanced and sophisticated treatment of the relations between religion and politics in a modern, secular society. (shrink)

We argue that while the proposed memory model by Bastin et al. can explain familiarity-based memory judgements through the interaction of a core representation system and an attribution system, recollection-based memory judgements are not based on non-mnemonic signals being attributed to memory.